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Any other increase of that magnitude would be cause for concern

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2 In a secondary endpoint, 37.1% of participants taking the highest dose of orforglipron achieved an A1C 14 days of use)

Mechanistic insights from sequential combination therapy with a sodium glucose co-transporter-2 inhibitor and a dipeptidyl peptidase4 inhibitor: results from the CANARIS Trial using canagliflozin and teneligliptin